I've Been Killing Slimes for 300 Years and Maxed Out My Level

An at-home comedy about a powerful girl who doesn’t work too hard!(⋈◍ ˃ᴗ˂ ◍)。✧♡ After dying of overwork in the real world, I’m reincarnated as an immortal witch, and I spend 300 years enjoying a relaxing life. At some point, though, I end up at level 99! All those years spent killing slimes to make the money to pay the bills gave me a ton of experience points… Rumors of the level 99 witch spread, and soon I’m up to my ears in curious adventurers, duelist dragons, and even a monster girl calling me her mom! “This isn’t a dojo, so don’t come here to fight me…!” I’ve never been on an adventure, but I’m the strongest in the world… What’s going to happen to my relaxing life?! (Source: Crunchyroll)

Drug Store in Another World - The Slow Life of a Cheat Pharmacist

Reiji Kirio was a corporate wage slave, who did nothing but work all day, every day. On a typical day of walking to work with a hollow look on his face, he suddenly found himself in the forest of another world. "Oh, this must be one of those isekai reincarnations people keep talking about." The two skills he has are "Appraise" and "Drug Discovery." Those don't sound too impressive... well, whatever. Except these turn out to be particularly overpowered skills! He's able to produce the healing medicines that were sorely lacking in the world, one after another, leading to an overnight fortune. No one will ever force him to work like a slave again! He decides to adopt a deliberately slow life, and opens a drug store. And so, a story about following the slow life philosophy while running a drugstore in another world begins.(Source: Crunchyroll)

The Saint's Magic Power is Omnipotent

Why would an overworked woman want to be summoned to a magical new world? To live her ideal life of leisure, of course! For Sei, it’s truly a dream: studying spells and perfecting potions at the institute while helping people with their problems. But keeping a low profile is proving to be difficult as her magical power becomes omnipotent. Can Sei hide away in this fantasy forever? She hopes so! (Source: Funimation)

By the Grace of the Gods

Only 39 years into a life full of bad luck, Ryouma Takebayashi passes away in his sleep! Taking pity on him, three divine beings show compassion by reincarnating him as a young boy to a magical, new world. Now he spends his time researching and caring for slimes. But after healing an injured traveler, Ryouma decides to set out with his new friends on a journey to use his power to help others. (Source: Funimation)

Kuma Kuma Kuma Bear

Yuna's not your typical 15-year-old. First, she's crazy rich from playing the stock market. Second, she's a recluse obsessed with a VRMMO game, and she's really good at that too. Her life is pretty much perfect—until she wakes up one day inside the game she loves and back at level one. She has to start over, but this time, she has a powerful bear suit that's guaranteed to take her places! (Source: Funimation) Note: The first episode was streamed on Abema TV on September 19, 2020. The regular TV broadcast started on October 7, 2020.</i>

Princess Connect! Re:Dive

Based on an anime RPG smartphone game by Cygames. Set in the lovely land of Astoria where a gentle wind blows, Princess Connect! Re:Dive</i> follows the adventures of: Yuuki, an amnesiac young man; Kokkoro, a small guide who looks after Yuuki; Pecorine, a beautiful swordswoman who is constantly hungry; and Karyl, a cat-eared magical girl with a somewhat cool personality. These fateful four form a guild entitled "Bishoku-den" ("Epicurean Hall") and embark on delicious adventures together. (Source: Crunchyroll)

BOFURI: I Don't Want to Get Hurt, so I'll Max Out My Defense.

The story centers on Kaede Honjou, who is invited by her friend Risa Shiramine to play a virtual reality MMO game with her. While Kaede doesn't dislike games, what she really, truly dislikes is being in pain. She creates a character named Maple, and decides to put all her points in VIT to minimize pain. As a result, she moves slowly, can't use magic, and even a rabbit can get the best of her. However, as it turns out, she acquires a skill known as "Absolute Defense" as a result of her pumping points into VIT, as well as a "Counter Skill" that works against special moves. Now, with her ability to nullify all damage, she goes on adventures.(Source: Anime News Network, edited)

The Rising of the Shield Hero

Naofumi Iwatani, an uncharismatic Otaku who spends his days on games and manga, suddenly finds himself summoned to a parallel universe! He discovers he is one of four heroes equipped with legendary weapons and tasked with saving the world from its prophesied destruction. As the Shield Hero, the weakest of the heroes, all is not as it seems. Naofumi is soon alone, penniless, and betrayed. With no one to turn to, and nowhere to run, he is left with only his shield. Now, Naofumi must rise to become the legendary Shield Hero and save the world! Note: - The first episode was pre-aired on December 27th, 2018. Regular broadcast began on January 9th, 2019. - The first episode aired with a runtime of ~47 minutes as opposed to the standard 24 minute long episode.</i>

Spice and Wolf

The peddler Kraft Lawrence travels through the world selling all kinds of things. After visiting a village, he discovers a sleeping girl under the pelts in his cart. She has wolf ears and a tail. The wolf girl explains that she has been called a "god", but that her name is Holo and nothing more. Lawrence teases the girl a little, but after hearing more of her story, he is moved and decides to accompany her further north. On their travels the two have many adventures, often getting into trouble, but the bond between them grows stronger.

Grimgar of Fantasy and Ash

Fear, survival, instinct. Thrown into a foreign land with nothing but hazy memories and the knowledge of their name, they can feel only these three emotions resonating deep within their souls. A group of strangers is given no other choice than to accept the only paying job in this game-like world—the role of a soldier in the Reserve Army—and eliminate anything that threatens the peace in their new world, Grimgar. When all of the stronger candidates join together, those left behind must create a party together to survive: Manato, a charismatic leader and priest; Haruhiro, a nervous thief; Yume, a cheerful hunter; Shihoru, a shy mage; Mogzo, a kind warrior; and Ranta, a rowdy dark knight. Despite its resemblance to one, this is no game—there are no redos or respawns; it is kill or be killed. It is now up to this ragtag group of unlikely fighters to survive together in a world where life and death are separated only by a fine line.

Wise Man’s Grandchild

A young man is reborn in another world where he is adopted as a baby by the hero Merlin Wolford and named Shin. By his 15th birthday, Shin has accumulated all kinds of power by studying under Merlin, but one thing his adoptive grandfather didn't give him was a lick of common sense. (Source: Anime News Network)

Miss Kobayashi's Dragon Maid

What happens when a drunken promise leads to living with a dragon? That’s Miss Kobayashi’s new reality when Tohru appears in her life. With a maid-slash-dragon in her home, she’s experiencing a whole new level of domestic bliss! But the dragons don’t stop there. On a mission to find Tohru appears Kanna, a little dragon with a big attitude. Before she knows it, Kobayashi’s got a house full of dragons—one serving tail and the other serving serious moe! Together, they live side by side with only the occasional disaster…well, maybe. But nothing beats coming home to the warm welcome of a dragon maid! (Source: Funimation)

Vampire Dormitory

“I want to become your thrall…!”</i> A crossdressing girl and doting vampire’s dangerous cohabitation is about to begin! After losing her parents and being abandoned by her relatives, Mito is left all alone in the world. When she’s kicked out of the restaurant where she works with no money and no place to live, she is taken in by Ruka, a vampire. In exchange for giving Ruka her blood as his “food,” she ends up living with him in a boys’ dorm full of beautiful boys with unique personalities…?! (Source: Crunchyroll)